There is growing evidence that traditional response to floods and flood-related disaster is no longer achieving desirable results. Nature-Based Solutions (NBS) represent a relatively new response towards disaster risk reduction, water security, and resilience to climate change, which has a potential to be more effective and sustainable than traditional measures. However, in practice, these measures are still being applied at a slow rate while traditional grey infrastructure remains as a preferred choice. This can be attributed to several barriers which range from political and governance to social and technological/technical. More generally, there is a lack of sufficient knowledge base to accelerate their wider acceptance and uptake. The present work provides contribution in this direction and addresses the question of effectiveness of different types of NBS (i.e., small- and large-scale NBS) and their hybrid combinations with grey infrastructure. The work has been applied on the case of Ayutthaya, Thailand. The results suggest that the effectiveness of small-scale NBS is limited to smaller rainfall events whereas the larger (or extreme) events necessitate combinations of different kinds of measures with different scales of implementation (i.e., hybrid measures).